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Wall Street Pauses as Tech Weakness Weighs on Futures

  U.S. stock futures were mixed as investors navigated lingering volatility following a sharp pullback in major technology names. Dow Jones futures showed a slight uptick, while S&P 500 futures hovered near flat. Nasdaq futures, however, continued to drift lower, reflecting ongoing pressure in the tech sector. The recent downturn in high‑growth technology stocks has prompted a broader shift in market sentiment, with traders rotating toward more defensive positions. Concerns about the sustainability of tech valuations and the impact of AI‑driven competition have added to the cautious mood. Attention now turns to Alphabet’s upcoming earnings report, which is expected to play a pivotal role in shaping the market’s next move. With investors eager for clarity on the company’s AI strategy and advertising performance, the results could either steady the tech landscape or deepen the current uncertainty.
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Alzheimer’s Drug Donanemab Receives FDA Advisers’ Endorsement for Slowing Disease Progression

 

A significant milestone has been reached in the fight against Alzheimer’s disease. Eli Lilly’s closely watched Alzheimer’s drug, donanemab, has won the unanimous backing of federal health advisers. The drug is specifically intended for people with mild dementia caused by this brain-robbing disease.

The decision by the Food and Drug Administration (FDA) advisers comes after careful consideration of the drug’s benefits and risks. Donanemab has demonstrated the ability to modestly slow cognitive decline and memory problems associated with Alzheimer’s. Although it’s not a cure, this endorsement represents a promising step forward in managing the disease.

Here are the key points:

  1. Effectiveness: Donanemab has shown effectiveness in slowing cognitive decline. Patients who received monthly intravenous infusions of the drug declined about 35% more slowly than those who received a placebo.
  2. Risk Assessment: The FDA panel weighed the risks, including side effects like brain swelling and bleeding, which will need monitoring. Despite these risks, the panel concluded that the drug’s benefits outweighed them.
  3. Tau Protein Screening: Unlike previous concerns about tau protein screening, most panelists believed there was enough evidence to prescribe the drug broadly without requiring such screening.
  4. FDA Decision: The FDA will make the final decision on approval later this year. If approved, donanemab would become only the second Alzheimer’s drug in the U.S. shown to convincingly slow cognitive decline.

This endorsement brings hope to individuals and families affected by Alzheimer’s, and we eagerly await the FDA’s final decision. Stay tuned for further updates on this groundbreaking development! 

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